ABSTRACT
OBJECTIVE: With the use of regular cervical cytologic screening, an increasing percent of patients with invasive cervical cancer are being diagnosed with early-stage disease. During the past two decades, there has been considerable interest in identifying a group of patients with early invasive cancer who have a minimal risk for extracervical spread. Method: From January 1993 to June 2000, we have experienced 26 cases with microinvasive cervical cancer. The data were collected retrospectively and all charts were reviewed. Result: The age ranged from 29 to 69 years and median age was 44.3 years. 18 cases incidentally found through the routine Pap smear, in symptomatic group most frequent initiating symptom was postcoital bleeding. The corresponding rate of Pap smear to histologic diagnosis was approximately 26.9%. However, corresponding rate within one histologic grade was about 69.2%. The modified radical abdominal hysterectomy was performed in 21 cases and modified radical abdominal hysterectomy with pelvic lymph node biopsy was performed in 4 cases and radical abdominal hysterectomy with pelvic node biopsy was done in 1 case with greater than 3 mm and no greater than 5 mm stromal invasion. There was no surgery-related deaths and recurrent cases in this study. CONCLUSION: The prognosis of stage Ia cervical cancer is relatively good and less radical therapeutic approach may be beneficial. But, further prospective study based on large numbers of cases with multi-institutional cooperation and designed protocol will be necessary.
Subject(s)
Humans , Biopsy , Diagnosis , Hemorrhage , Hysterectomy , Lymph Nodes , Mass Screening , Prognosis , Retrospective Studies , Uterine Cervical NeoplasmsABSTRACT
A case of diffuse malignant mesothelioma of peritoneum which was difficult to distinguish from metastatic anaplastic carcinoma or malignant melanoma was presented. The patient was a 50 year-old woman and complained of an abdominal pain and ascites for 20 days. Histologically, the tumor cells showed highly anaplastic appearance with sheet-like arrangement without any papillary or tubular structure. They stained Positive for cytokeratin and vimentin and negative for CEA, S-100 protein and melanoma associated antigen. A few cells within the tumor showed Positive reactivity to desmin. Ultrastructurally, the tumor cells had characteristic findings of mesothelioma such as long, exuberant, wavy microvilli with 10 to 12 of length/diameter ratio. The patient died 3 months after the diagnosis in spite of intraperitoneal chemotherapy.
Subject(s)
Female , Humans , Neoplasm MetastasisABSTRACT
A solitary, asymptomatic lesion, clinically resembling a transpare it cyst, has been present for 4 months in the vaginal mucosa of a 43-year-old healthy woman. An xcisional biopsy revealed the lesion to be a focal accumulatition of hyaluronic acid replacing the collagen fibers and fibroblastic proliferation in the dermis consistant with cutaneous focal mucinosis. During the follow-up period for 3 months, no recurrence was observed.
Subject(s)
Adult , Female , Humans , Biopsy , Collagen , Dermis , Fibroblasts , Follow-Up Studies , Hyaluronic Acid , Mucinoses , Mucous Membrane , RecurrenceABSTRACT
A solitary, asymptomatic lesion, clinically resembling a transpare it cyst, has been present for 4 months in the vaginal mucosa of a 43-year-old healthy woman. An xcisional biopsy revealed the lesion to be a focal accumulatition of hyaluronic acid replacing the collagen fibers and fibroblastic proliferation in the dermis consistant with cutaneous focal mucinosis. During the follow-up period for 3 months, no recurrence was observed.